Perinatal Infections

GBS
Prevention: Intrapartum Penicillin G or Clindamycin/Erythromycin

1. All women with positive GBS urine culture
2. Previous neonatal sepsis
3. Trimester vaginal culture positive
4. Preterm gestation
5. Membranes rupture > 18 h
6. Maternal fever

Toxoplasmosis

• Chorioretinitis
• Intracranial calcification
• Symetrical IUGR
• Hepatosplenomegaly
• Thrombocytopenia
• Primary infection cause problems
  

Treatment:

1. Pyrimethamine and sulfadiazine
2. Spiramycin to prevent vertical transmission

Varicella

• Microphthamia
• Extremity hypoplasia
• Zigzag rashes
• Greatest risk if rashes occur 6 days antepartum or 2 days postpartum

Prevention: VZIG, attenuated VZ
Treatment: Acyclovir

Rubella

• Congenital deafness
• Congenital cataracts
• Congenital heart disease
• Primary infection causes problems

Prevention: all pregnant women should be screened for IgG. Active vaccination after delivery

CMV

• Nonimmune hydrops
• Symmetric IUGR
• Periventricular calcification
• Congenital deafness
  

Treatment: Ganciclovir

HSV

• If genital herpes presents, C-section
• Acyclovir