Precocious puberty

Precocious puberty: girl <=8, boy <=9 Thelarche, adrenarche, growth spur, menarche: 9, 10, 11, 12 Incomplete Isosexsual: only one (Txt: conservative) Complete Isosexsual: all four A. Gonadotropin dependent: idiopathic (Txt: GnRH Agonist) or CNS B. Gonadotropin independent: 1. McCune-Albright syndrome: Txt: aramotase inhibitor

2. Granulosa cell tumor