Primary amenorrhea

Dx:
1. No secondary sexual dev: without menses at 14
2. With secondary sexual dev: without menses at 16

Differentiation: breast and uterus is the key
1. (+)breast (+)uterus: many reasons,

2. (+)breast (-) uterus: Mullerian Agenesis and Androgen Insensitivity, to differentiate these two, simply look if pubic hair present. AI doesn't have pubic hair.

3. (-)breast (+)uterus: Turner or Hypothalamic-Pituitary failure, look for FSH. FSH high in Turner.