RA

T-cell caused disease, mediated by TNF-a, IL-1, IL-6
very rare in HIV

Never involved: 1. DIP, 2. lower back

felty syndrome: RA+splenomegaly+neutropenia

COX-2 inhibitors rofecoxib, valdecoxib increase myocardial infarct and stroke risk, celecoxib does not

Infliximab: sepsis, TB, and other opportunistic infection
Adalimumab: longer half-life
Etanercept: TB

Atlantoaxial subluxation: paraplegia, quadriplegia, neck pain, c2 radicular pain, myelopathy
X-ray for cervical spine

All RA needs X-ray for C1, C2 before intubation or anesthesia

swollen painful calf: ruptured baker cyst